Cloning stem cells: What does it mean?
(CNN) — A human embryo, containing about a couple hundred cells, is smaller than the period at the end of a sentence. Scientists need strong microscopes to see these precursors to life, and to take from them stem cells, which have the potential to become any cell in the body.
Earlier this week a breakthrough in this field was announced. A group of researchers published in the journal Cell proof that they had created embryonic stem cells through cloning. The scientists produced embryos using human skin cells, and then used the embryos to produce stem cell lines.
“It is an incredibly powerful approach with potential to generate almost any tissue in the body, genetically identical to the patient,” said Jeff Karp, associate professor at Harvard Medical School and co-director of the Center for Regenerative Therapeutics at the Brigham and Women’s Hospital in Boston.
Creating an embryo just from an egg and a skin cell seems like magic, but just how practical would the subsequent stem cells be? And does it actually amount to cloning?
What they did
Normally, an embryo is created when sperm enters the egg and it starts to divide. But, in the Cell study, Shoukhrat Mitalipov and colleagues at Oregon Health and Sciences University began with skin cells from an 8-month-old baby that had a genetic disease. They did not use sperm.
To create each embryo, they took the DNA out of an egg, so that it was hollow, and replaced it with the skin cell’s DNA instead. The baby’s DNA was the only genetic material being used.
With the help of chemicals, the egg started to divide just like a normal fertilized egg would. Then, within several days, embryos genetically identical to the baby were created, from which stem cells were derived.
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Embryonic stems research is inherently controversial because in order to use the stem cells for science, the embryo, which is a collection of cells that could develop into a fully formed human, is destroyed, even though embryos in these procedures are left over from in vitro fertilization.
However, Mitalipov said the embryos created in his study, from skin cells and eggs, would not grow babies. That would have required additional technology, and it wasn’t part of the study.
While cloning stem cells is a technical breakthrough, there’s already a method of deriving embryonic-like stem cells that doesn’t require the use of embryos at all: induced pluripotent stem (IPS) cells, said Dr. George Daley, who is director of the Stem Cell Transplantation Program at Children’s Hospital Boston and an international expert in stem cells.
Induced pluripotent stem cells can come from any cell in the human body, including skin cells, so they don’t have the moral quandaries surrounding them. Researchers have developed methods of inserting genes to “turn back the clock” on cells that have already specialized, so that they can turn into anything again. It doesn’t matter what the cell was before; it can now be reprogrammed as any kind of cell researchers want.
The new study involves a complex method that requires women to donate eggs, and a demanding manipulation of cell components on a tiny scale, Daley said.
What remains to be seen is whether these cloned embryonic stem cells are more useful therapeutically than the noncontroversial induced pluripotent stem cells, and questions linger about their effectiveness.
What’s the best type of stem cell
Ethical questions aside, researchers say they need to explore both embryonic and induced pluripotent stem cells in order to see what works best for various diseases and conditions.
Safety concerns linger around induced pluripotent stem cells because they were first created inserting four new genes.
“Remember, this was a genetic manipulation that was done to generate those cells, and there is concern that (for) anything you derive from them and you put back in the patient as graft, you may be at risk,” said John Gearhart, director of the Institute for Regenerative Medicine at the University of Pennsylvania, and one of the leading pioneers of stem cell research.
New techniques have been developed, however, to make induced pluripotent stem cells without permanent genetic modifications that were associated with tumors.
In mice, Daley and colleagues have shown that stem cells derived from the nuclear transfer of cells to make embryos — the technique described in Mitalipov’s paper — were indeed closer to natural embryo stem cells than induced pluripotent stem cells. The differences were so subtle that they may not be meaningful, however, he said.
The new study involves something similar to the cloning technique that led to the birth of Dolly, the famous cloned sheep that was born in July 1996. But making embryos for reproduction would require more advanced, complex techniques than were used in the new study — and serious scientists do not endorse human cloning for reproduction.
Mitalipov, senior author on the paper, laughs when asked if he wants to clone a person. “No, of course not,” he said.
“We tried the same approach to clone monkeys, because we’d been interested for biomedical research to produce cloned monkeys, and it never worked,” he said. “We’ve been working for a decade in that area.”
Mitalipov and colleagues had no intention of this research leading to the birth of a cloned human.
Researchers say there have been so many health problems in cloned animals, including Dolly herself, that it would not be ethical to attempt to create a cloned human.
“No legitimate scientist would be stepping forward to apply this in reproductive cloning, or for fertility work,” Daley said. “I would argue that really there are no good medical reasons to generate a cloned baby.”
So what is it good for?
There’s one important area where experts say Mitalipov’s method could have tremendous implications: Mitochondrial disease.
The mitochondria are the “power plants” of cells, supplying them with chemical energy. DNA in the mitochondria is inherited entirely from the mother’s egg, unlike the DNA in the cell’s nucleus, which comes from both parents.
Mutations in mitochondrial DNA can lead to deadly diseases, and their associated mutations are passed down to each new generation. Induced pluripotent stem cells preserve these harmful mutations, says Mitalipov.
A cell’s mitochondrial DNA develops mutations over the course of a lifetime, little by little, and may result in diseases such as Parkinson’s disease and diabetes, Milapotov said. It’s possible, he says, that one day there will be stem cell treatments for aging and age-related diseases.
The only way to ensure that stem cells derived from an adult patient do not have mitochondrial DNA mutations would be to use the technique demonstrated in the new study, Milapotov said: Creating embryos with cells from the patient’s own body, and healthy eggs, for the purpose of deriving embryonic stem cells.
“You want 0 miles in that rejuvenated cells that you want to put back into these patients,” he said. “The 0 mileage engine is in the egg.”
Mitalipov’s group also demonstrated in a 2012 Nature study that it could be possible to, using genetic techniques, reconstruct embryos that would not have the unhealthy mitochondrial mutations. This is not cloning, but draws on similar knowledge, and could cure a family’s genetic disease lineage in the future.
What’s next?
Daley estimates human clinical trials in stem cells will start within one to three years, but perhaps it could take a decade or more before the impact of stem cell therapy becomes widespread.
Gearhart is confident that the more we learn how to manipulate stem cells safely, there will be safe way to provide them to patients who need them. But there are different levels of risk for different uses. There will always be a risk-benefit calculation to be made, he said.
Different areas of stem cell research have proven to be harder than others. Beta cells for type I diabetes have been “a very difficult nut to crack,” Gearhart said, but there have been promising developments in repairing the heart, something that his lab has worked on, as well as for eye diseases.
“I think it’s going to be exciting times over the next several years when it comes to this,” he said.
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Deborah Knight, the grandmother of kidnapping victim Michelle Knight, participates in a community balloon-release service in Michelle’s honor on Thursday, May 9, in Cleveland. Four females were found in a home on Seymour Avenue in the Clark Fulton neighborhood on Monday. Since then, the neighborhood and the nation have wondered how they were held captive without anyone noticing sooner.
Authorities say Ariel Castro held three women — Amanda Berry, Gina DeJesus and Michelle Knight. DNA tests confirmed that he fathered a girl born to Berry, who was among those rescued, the Ohio attorney general’s office said Friday. His house, third from left, is now a crime scene.
57-year-old Ronice Dunn moved into the neighborhood in 1984. For years after Berry and DeJesus disappeared, she joined in neighborhood vigils and prayer groups for their safe return.
A building sits boarded up on Seymour Avenue. The Clark Fulton neighborhood is beset by nearly double-digit unemployment, and one in every five houses is in foreclosure.
The media set up tents near Castro’s home. 
Kinkel Avenue is a few blocks from Castro’s home. 
The house of Onil Castro’s two sons, where he was staying when he was arrested on Kinkel Avenue. He and his brother Pedro were arrested along with Ariel Castro, but later were released and not charged. 
“Why didn’t I notice anything? What should I have been looking for?” asked Mickie Wodgik, who spent years living across the street from Castro and, it turns out, the three missing women. 
Around the corner from Seymour Avenue, graffiti is written on an abandoned building.
A street view shows West 25th Street, which runs perpendicular to Seymour Avenue.
Cynthia Conor, who has lived in the same house for 38 years, often drank with Castro and and his brother Pedro, she said. Her father trained Castro for his school bus job.
A man stands on Clark Avenue in front of painted buildings. 
This boarded-up building sits across the street from Castro’s house.
Pastor Joe Abraham has ministered to many in this neighborhood for more than 25 years, including as the leader of Scranton Road Bible Church.
People hold balloons during a community balloon-release service in kidnapping victim Michelle Knight’s honor. 
Residents gather outside a community meeting at Immanuel Lutheran Church on Thursday, May 9, to talk about the kidnapping case in Cleveland. Balloons were released as part of the ceremony. Gina DeJesus, Amanda Berry and Michelle Knight escaped on Monday, May 6, after being held captive for nearly a decade.
FBI agents and other law enforcement officers stand outside suspect Ariel Castro’s home in Cleveland on May 9. Castro, a former school bus driver, has been accused of holding three women captive for a decade in his house. He has also been charged with rape.
Castro hangs his head low while talking with his public defender, Kathleen DeMetz, during his arraignment on May 9.
Ada Colon prays during a vigil held in honor of the kidnapping victims in Cleveland on Wednesday, May 8.
Relatives of kidnapping victim Georgina “Gina” DeJesus hug after she returned to her parents’ home in Cleveland on May 8.
Friends and neighbors cheer as a car carrying Amanda Berry arrives at her sister’s house in Cleveland on May 8.
Gina DeJesus gives a thumbs up as she arrives at her family’s house in Cleveland on May 8.
Ariel Castro was charged on May 8 with kidnapping the three women.
The family house of Gina DeJesus has been decorated by well-wishers on Tuesday, May 7.
Friends and relatives gather in front of the family house of DeJesus on May 7.
Well-wishers visit the home of the sister of Amanda Berry on Monday, May 6.
Investigators remove evidence from the house on Seymour Avenue in Cleveland where the three women were held.
An FBI forensics team meets outside the house where three women were held as they investigate the property.
An FBI forensics team member removes evidence from the house.
A relative of DeJesus brings balloons to the home of Amanda Berry’s sister in Cleveland on May 7.
Children hold a sign and balloons in the yard of Gina DeJesus’ family home in Cleveland on May 7.
Bystanders and media gather on May 7 along Seymour Avenue in Cleveland near the house where the three women were held captive.
A bystander shows the front page of The Plain Dealer newspaper to a friend outside of the house on Seymour Avenue on May 7.
Cleveland Deputy Chief of Police Ed Tomba, center, speaks at a news conference to address details of the developments.
The house where the three women were held captive in Cleveland was the home of Ariel Castro, who was arrested and is being held pending charges in the case.
FBI agents remove evidence from the houseMay 7.
A police officer stands in front of the broken front door of the house on May 7, where the kidnapped women escaped.
Neighbor Charles Ramsey talks to media as people congratulate him on helping the kidnapped women escape on Monday, May 6. He helped knock down the door after he heard screaming inside.
Amanda Berry vanished a few blocks from her Cleveland home on April 21, 2003. She was 16.
Georgina “Gina” DeJesus was last seen in Cleveland on April 2, 2004, on her way home from school. She was 14 when she went missing.
Michelle Knight was last seen on August 22, 2002, when she was 21.
On June 5, 2002, when Elizabeth Smart was 14, she was abducted from her bed, raped and held captive for nine months by Brian David Mitchell. On May 25, 2011, Mitchell was sentenced to life in prison.
Natascha Kampusch, an Austrian woman, was held prisoner in a basement for eight years from the time she was 10. Her abductor, Wolfgang Priklopil, beat her up to 200 times a week, manacled her to him as they slept and forced her to walk around half-naked as a domestic slave after kidnapping her in 1998. Kampusch escaped in August 2006. Priklopil committed suicide shortly thereafter.
Eleven-year-old Jaycee Lee Dugard was abducted in 1991 from outside her home in South Lake Tahoe, California. She was held by Phillip and Nancy Garrido in a hidden compound of sheds along with the two daughters to whom she subsequently gave birth. Dugard and her daughters were found in 2009.
Shawn Damian Hornbeck spent more than four years with Michael Devlin, passing as his captor’s son in the St. Louis suburb of Kirkwood, Missouri. Shawn was 15 when he was found in 2007 and reunited with his family. 
Elisabeth Fritzl was imprisoned and raped by her father, Josef Fritzl, for 24 years. Fritzl lured his daughter into the basement in 1984 when she was 18 years old. She had seven of his children. She was released at age 42 after her ill 19-year-old daughter was taken to the hospital and police called the family in for abuse suspicions. In 2009 Josef Fritzl was sentenced to life in prison. 
Carlina White was abducted in 1987 from a Harlem hospital room. She learned her real identity 23 years later after finding her case online. She contacted the police after finding a baby picture that looked like her baby pictures on a missing children website. She was reconnected with her birth mother in 2011. White said she’d never felt like she belonged to the family who raised her.
Steve Carter also discovered he was a missing person after an online search. He had been adopted at age 4 from an orphanage in Honolulu. At 35 years old, he heard about White’s case and clicked on Missingkids.com and found an age progression photo of himself as an infant. It came to light that biological father, Mark Barnes, reported him missing more than three decades ago after his mother, Charlotte Moriarty, took him for a walk and didn’t return.
Rescue workers carry Reshma Begum, 19, to safety on Friday, May 10, a day after her discovery alive amid the wreckage of a building that had entombed her since it collapsed on April 24, in Dhaka, Bangladesh. At least 1,127 people have been confirmed dead from the garment factory building collapse.
Begum, a young female garment worker at the Rana Plaza building before the disaster, addresses the media at the Savar Combined Military Hospital in Savar area of Dhaka on Monday, May 13.
Throngs of reporters crowd around Begum as she speaks publicly for the first time on May 13 about her ordeal in Dhaka. 
Begum is surrounded by media and members of the Bangladeshi military at the hospital where she is recovering in Dhaka on May 13.
A nurse helps Begum through a door as she attends a media conference at the Savar Combined Military Hospital in Dhaka on May 13.
Begum rests in her hospital bed as members of the Bangladeshi military stand beside her at the Savar Combined Military Hospital in Dhaka on Saturday, May 11.
Begum was found in the factory’s basement in a pool of water, according to rescue official Lt. Col. Moazzem Hossain.
Bangladeshi army workers supervise the continued rescue operation using heavy equipment to sift through the rubble on May 10 in Dhaka.
Rescuers workers administer first aid as they carry Begum from the rubble on May 10 in Dhaka.
Begum is pulled alive from the rubble by the rescue workers on May 10, after being buried for 16 days.
Begum recalled that when the collapse of the nine-story building began, she was working on the third floor. She was found in the factory’s basement.
The 19-year-old mother vowed to never again work in the country’s garment industry, where she was earning the equivalent of $60 a month.
Members of the Bangladesh army pray at the site of the collapsed Rana Plaza in Savar near Dhaka on Tuesday, May 14. The army-led effort to search for bodies has ended nearly three weeks after the nine-story building collapsed. The final death toll stands at 1,127.
Relatives of missing garment workers offer prayers in front of the rubble on May 14 in Savar.
A white board at the recovery command center near the disaster is used to track the death toll on Monday, May 13.
Heavy equipment sifts through the rubble of the garment factory building collapse on Sunday, May 12. 
A woman cries holds a portrait of a missing relative believed to be trapped in the rubble of the Rana Plaza building on Saturday, May 11.
Relatives search through a long line of covered decomposing bodies to try to identify their family members on May 11.
An injured worker who survived the building collapse is carried by her husband to collect her wages in Savar near Dhaka, Bangladesh, on Wednesday, May 8.
Garment workers who survived the building collapse line up to collect their salaries in Savar on May 8.
Workers continue rescue and recovery operations on Tuesday, May 7, nearly two weeks after the Rana Plaza building’s collapse outside Dhaka. 
Rescue workers recover a body from the rubble on May 7.
Relatives place a body in the back of a truck on May 7.
A woman attempts to identify one of the bodies kept in a schoolyard on May 7.
Members of the Bangladeshi army and firefighters carry the body of a garment worker from the scene of the building collapse in Savar, outside Dhaka, on Sunday, May 5. 
A woman holds a portrait of her missing relative as she sleeps on Saturday, May 4.
Relatives attempt to identify the bodies of loved ones on May 4.
Rescue workers dig out debris from the Rana Plaza building as Bangladeshi army personnel continue the second phase of a rescue operation using heavy equipment on Friday, May 3.
A woman reacts on May 3 after identifying a body found in the rubble.
A man stands amid the destruction as rescue and army personnel continue recovery operations on May 3.
A woman holds up a picture of a missing person believed to be trapped in the rubble on May 3.
A garment worker rescued from the wreckage of the Rana Plaza building lies in a hospital in Dhaka on Thursday, May 2.
A woman weeps after identifying her daughter’s body in the rubble in Savar on May 2.
Rescue workers move debris as Bangladeshi army personnel continue the second phase of a rescue operation at the site of the collapsed building in Savar on May 2.
A woman mourns before a mass burial in Dhaka on Wednesday, May 1.
Unidentified bodies from the rubble lie on the ground as people gather for a mass burial in Dhaka on May 1.
Workers dig graves during a mass burial of unidentified garment workers on May 1.
Sohel Rana, owner of the collapsed Rana Plaza building, wears police-issued body armor and a helmet while being escorted to court in Dhaka on Tuesday, April 30. Rana was arrested near the Indian border, and protesters called for him to be hanged.
Bangladeshi troops carry the body of a garment worker out of the rubble of the collapsed Rana Plaza building in Savar on April 30.
Clothing with Joe Fresh labels lies in the debris on April 30.
Cranes operated by Bangladeshi army personnel work on Monday, April 29.
Firefighters try to control a blaze that started while they were trying to rescue a woman with heavy equipment on April 29.
Bangladeshi army personnel begin the second phase of the rescue operation using heavy equipment on April 29.
Rescuers look for survivors on Sunday, April 28. The Bangladesh Red Crescent Society says the chances of finding anyone alive in the rubble at this date are remote.
A woman mourns on April 28 at the site of the building collapse in Savar. 
Rescue workers search for survivors on April 28.
Volunteers sleep before they begin more rescue operations on April 28.
Rescue workers carry a victim’s body recovered from the rubble on April 28.
Clothes lie in the rubble on Saturday, April 27.
An arrested owner of a garment factory is escorted to an appearance at the court in Dhaka on April 27. Four people were arrested and four others are being questioned by police.
Relatives hold photos of missing and dead workers outside the factory April 27.
Two Bangladeshi women look at a board with notices posted of missing and dead workers on April 27.
Bangladeshi relatives and workers load a body onto a truck on April 27.
An excavator operated by the Bangladeshi Army removes debris on April 26.
Volunteers and rescue workers conduct rescue operations on April 26.
Rescue workers use textile as a slide to move bodies out of the rubble on April 26.
Rescue workers look for trapped garment workers on April 26.
Rescue workers stand on the rubble of the collapsed building on April 26.
Rescue workers search the rubble for victims and survivors on April 26.
A rescue worker looks for trapped workers on April 26.
Bangladeshi army personnel recover a survivor from rubble on April 26, 48 hours after the collapse.
Volunteers and rescue workers assist in rescue operations on April 26.
A physician assists a survivor after he was recovered from the rubble on April 26.
Two bodies clutch each other in the rubble on Thursday, April 25.
People rescue garment workers on April 25.
A Bangladeshi woman shows a picture of her missing daughter-in-law she believes is trapped in the collapsed building on April 25.
Bangladeshi firefighters cut a hole through concrete during rescue operations on April 25 in Savar, a suburb of Dhaka.
Volunteers and rescue workers work at the scene on April 25. 
A woman appears devastated on April 25 after identifying the body of her husband killed in the building collapse.
Bangladeshi garment workers help evacuate a survivor by using a roll of fabric on April 24.
People rescue garment workers on Wednesday, April 24, after the building caved in, leaving a chaotic mass of broken concrete and twisted metal.
Relatives who lost a brother mourn outside a hospital on April 24. 
Rescuers help an injured garment worker to escape from the Rana Plaza building on the outskirts of Dhaka on April 24. 
Civilians help an injured garment worker on April 24. Work was proceeding slowly to avoid causing further collapse, an official said.
Rescue workers search for trapped garment workers in the Rana Plaza building on April 24.
An injured Bangladeshi lies on the hospital floor on April 24.
The injured receive treatment at a hospital on April 24.
An injured person rests in a hospital bed on April 24.
People wait anxiously on April 24 while rescuers search for survivors.
Rescuers help an injured person out of the seventh floor on April 24. 
Civilians help out in rescue efforts at the collapsed building on April 24. 
Hundreds watch the rescue operations on April 24.
People search for garment workers trapped under the debris on April 24.
Rescuers help an injured worker on April 24.
A body is trapped under the damaged building on April 24.
A woman is carried away from the building on April 24.
A rescue worker carries a worker to an ambulance on April 24.
Crowds gather around the collapsed building on April 24.
Rescuers bring out an injured garment worker from the building’s sixth floor.
Seventeen days after a building collapsed in Savar, Bangladesh, rescuers pull Reshma Begum from the rubble on May 10. More than 1,000 people have died since the nine-story garment factory building fell on April 24.
An officer of the Italian cruise line Costa Concordia, Manrico Giampedroni, is found 36 hours after the ship ran aground off the Mediterranean island of Giglio on January 13, 2012. He broke his leg as the liner rolled was was found in a half-flooded dining room, suffering from hypothermia.
A baby, her mother and her grandmother are rescued in eastern Turkey on October 25, 2011, two days after a 7.2-magnitude earthquake killed more than 600 people. Dramatic video showed 2-week-old Arza Karaduman being carried from the debris of a multiple-story building.
More than 9 miles out at sea, a 60-year-old Japanese man is found clinging to the swept-away remnants of his home on March 13, 2011. Hiromitsu Shinkawa was drifting alone for more than two days after a massive Japanese earthquake and tsunami.
Anne Vos, 57, is rescued 24 hours after a five-story building where she worked collapsed during an earthquake in Christchurch, New Zealand, on February 22, 2011. She said she thought she was going to die and had called family and friends to say goodbye. She talked to international media while trapped.
After 69 harrowing days underground and a rescue mission costing up to $20 million, 33 Chilean miners are rescued on October 13, 2010. The mine collapsed on August 5, leaving the workers trapped 2,300 feet beneath the Earth’s surface.
Digging through the mud, Chinese soldiers rescue Liu Ma Shendeng from the second story of an apartment building on August 10, 2010. The 52-year-old man was trapped for 60 hours after massive mudslides buried homes and ripped others apart in China’s Gansu province. The death toll climbed to more than 1,400.
Nine-year-old Ruben van Assouw is the sole survivor of a plane crash in Tripoli, Libya, on May 14, 2010. His parents and brother are among the 103 people killed.
A man identified as Evan Muncie, 28, is found in the ruins of a marketplace, his family tells CNN, nearly a month after a 7.0-magnitude earthquake devastated Haiti on January 12, 2010. He suffered from extreme dehydration and malnutrition, but did not appear to have significant crushing injuries, doctors said.
A 13-year-old girl is found in the Indian Ocean clinging to plane debris after the Yemenia Airways Airbus A310 from France crashed on June 1, 2009. Bahia Bakari was the sole survivor of the crash. She had been flying with her mother.
Naqsha Bibi, 40, is recovered alive from the debris of her collapsed home in Kashmir on December 12, 2005. She reportedly survived on rainwater and rotting food for more than 60 days after an earthquake struck the region on October 8.
Rashida Farooq, a 45-year-old mother of three, is rescued from her home 105 hours after it collapsed in Muzaffarabad, Pakistan, on October 12, 2005. The 7.6-magnitude earthquake that hit the country killed 80,000 people.
A man identified as Jalil, 57, is rescued 13 days after an earthquake in Bam, Iran, on December 26, 2003. He was trapped under a closet and must have had access to water, an Iranian doctor told Reuters.
After being trapped for more than three days, nine miners are rescued from the Quecreek coal mine in Somerset, Pennsylvania, on July 28, 2002. They were caught in a 4-foot-high chamber 240 feet underground after breaching a wall separating their mine from an older, flooded shaft on July 24.
Genelle Guzman-McMillan is rescued from the debris of the World Trade Center 26 hours after the terrorist attack on September 11, 2001. She worked on the 64th floor of the north tower and was walking down a stairwell when the building collapsed. Her body was protected in an air pocket.
Shiran Franco, a 9-year-old Israeli girl, is rescued on August 21,1999, around 100 hours after a building collapsed on her during an earthquake in Cinarcik, Turkey. Her family had been on vacation. Shiran’s twin brother, father and grandparents were found dead, but her mother survived after pulling herself from the building after 30 hours.
Three infants are pulled alive from the crumbled Benito Juarez Hospital seven days after a powerful earthquake hit the Mexican capital on September 19, 1985. With more than 10,000 people killed, the newborns became known as the “miracle babies” of Mexico City.
Sixteen people are rescued 72 days after a Uruguayan Air Force plane crashed in the Andes Mountains on October 13, 1972. They endured frigid temperatures and forced themselves to eat the flesh of dead friends to sustain themselves. A dozen of the 45 passengers on board died in the crash. Others later succumbed to their injuries.
Marching Bangladeshis hold up portraits of relatives missing in the Rana Plaza building collapse on Tuesday, May 14. They’re demanding wages for the missing garment workers and the death sentence for the building owner. Rana Plaza collapsed on April 24 in Savar outside Dhaka; the final death toll stands at 1,127.
Family members of missing workers march on May 14. The Bangladeshi army has wrapped up its search for bodies.
Bangladeshi property tycoon Sohel Rana, center, is escorted to the High Court in Dhaka wearing police-issued body armor as protests calling for his prosecution continue, Tuesday, April 30. 
Bangladeshis march on April 30, demanding capital punishment for Rana in Savar, Bangladesh, outside the capital, Dhaka. 
Garment workers block a street during a protest Monday, April 29.
Bangladeshi garment workers protest in Savar on Saturday, April 27. Four people were arrested and four others are being questioned by police. The building owner has gone into hiding.
Bangladeshi army personnel and police from villagers on Friday, April 26, after protests broke out at the site of a building collapse 48 hours earlier in Savar, outside Dhaka. 
Garment workers block a street in Savar, demanding the arrest of the owner of the Rana Plaza building.
Bangladeshi police fire tear gas at protesters amid the rubble of the building.
Garment workers block a street as they march to demand the arrest of the owner of the Rana Plaza building.
Plainclothes Bangladeshi police brandish sticks as they attempt to break up protests.
Firefighters work after protesters set fire to a spinning mill in Gazipur.
A man cleans up a restaurant after protesters broke its windows.
Rescue workers carry Reshma Begum, 19, to safety on Friday, May 10, a day after her discovery alive amid the wreckage of a building that had entombed her since it collapsed on April 24, in Dhaka, Bangladesh. At least 1,127 people have been confirmed dead from the garment factory building collapse.
Begum, a young female garment worker at the Rana Plaza building before the disaster, addresses the media at the Savar Combined Military Hospital in Savar area of Dhaka on Monday, May 13.
Throngs of reporters crowd around Begum as she speaks publicly for the first time on May 13 about her ordeal in Dhaka. 
Begum is surrounded by media and members of the Bangladeshi military at the hospital where she is recovering in Dhaka on May 13.
A nurse helps Begum through a door as she attends a media conference at the Savar Combined Military Hospital in Dhaka on May 13.
Begum rests in her hospital bed as members of the Bangladeshi military stand beside her at the Savar Combined Military Hospital in Dhaka on Saturday, May 11.
Begum was found in the factory’s basement in a pool of water, according to rescue official Lt. Col. Moazzem Hossain.
Bangladeshi army workers supervise the continued rescue operation using heavy equipment to sift through the rubble on May 10 in Dhaka.
Rescuers workers administer first aid as they carry Begum from the rubble on May 10 in Dhaka.
Begum is pulled alive from the rubble by the rescue workers on May 10, after being buried for 16 days.
Begum recalled that when the collapse of the nine-story building began, she was working on the third floor. She was found in the factory’s basement.
The 19-year-old mother vowed to never again work in the country’s garment industry, where she was earning the equivalent of $60 a month.
Members of the Bangladesh army pray at the site of the collapsed Rana Plaza in Savar near Dhaka on Tuesday, May 14. The army-led effort to search for bodies has ended nearly three weeks after the nine-story building collapsed. The final death toll stands at 1,127.
Relatives of missing garment workers offer prayers in front of the rubble on May 14 in Savar.
A white board at the recovery command center near the disaster is used to track the death toll on Monday, May 13.
Heavy equipment sifts through the rubble of the garment factory building collapse on Sunday, May 12. 
A woman cries holds a portrait of a missing relative believed to be trapped in the rubble of the Rana Plaza building on Saturday, May 11.
Relatives search through a long line of covered decomposing bodies to try to identify their family members on May 11.
An injured worker who survived the building collapse is carried by her husband to collect her wages in Savar near Dhaka, Bangladesh, on Wednesday, May 8.
Garment workers who survived the building collapse line up to collect their salaries in Savar on May 8.
Workers continue rescue and recovery operations on Tuesday, May 7, nearly two weeks after the Rana Plaza building’s collapse outside Dhaka. 
Rescue workers recover a body from the rubble on May 7.
Relatives place a body in the back of a truck on May 7.
A woman attempts to identify one of the bodies kept in a schoolyard on May 7.
Members of the Bangladeshi army and firefighters carry the body of a garment worker from the scene of the building collapse in Savar, outside Dhaka, on Sunday, May 5. 
A woman holds a portrait of her missing relative as she sleeps on Saturday, May 4.
Relatives attempt to identify the bodies of loved ones on May 4.
Rescue workers dig out debris from the Rana Plaza building as Bangladeshi army personnel continue the second phase of a rescue operation using heavy equipment on Friday, May 3.
A woman reacts on May 3 after identifying a body found in the rubble.
A man stands amid the destruction as rescue and army personnel continue recovery operations on May 3.
A woman holds up a picture of a missing person believed to be trapped in the rubble on May 3.
A garment worker rescued from the wreckage of the Rana Plaza building lies in a hospital in Dhaka on Thursday, May 2.
A woman weeps after identifying her daughter’s body in the rubble in Savar on May 2.
Rescue workers move debris as Bangladeshi army personnel continue the second phase of a rescue operation at the site of the collapsed building in Savar on May 2.
A woman mourns before a mass burial in Dhaka on Wednesday, May 1.
Unidentified bodies from the rubble lie on the ground as people gather for a mass burial in Dhaka on May 1.
Workers dig graves during a mass burial of unidentified garment workers on May 1.
Sohel Rana, owner of the collapsed Rana Plaza building, wears police-issued body armor and a helmet while being escorted to court in Dhaka on Tuesday, April 30. Rana was arrested near the Indian border, and protesters called for him to be hanged.
Bangladeshi troops carry the body of a garment worker out of the rubble of the collapsed Rana Plaza building in Savar on April 30.
Clothing with Joe Fresh labels lies in the debris on April 30.
Cranes operated by Bangladeshi army personnel work on Monday, April 29.
Firefighters try to control a blaze that started while they were trying to rescue a woman with heavy equipment on April 29.
Bangladeshi army personnel begin the second phase of the rescue operation using heavy equipment on April 29.
Rescuers look for survivors on Sunday, April 28. The Bangladesh Red Crescent Society says the chances of finding anyone alive in the rubble at this date are remote.
A woman mourns on April 28 at the site of the building collapse in Savar. 
Rescue workers search for survivors on April 28.
Volunteers sleep before they begin more rescue operations on April 28.
Rescue workers carry a victim’s body recovered from the rubble on April 28.
Clothes lie in the rubble on Saturday, April 27.
An arrested owner of a garment factory is escorted to an appearance at the court in Dhaka on April 27. Four people were arrested and four others are being questioned by police.
Relatives hold photos of missing and dead workers outside the factory April 27.
Two Bangladeshi women look at a board with notices posted of missing and dead workers on April 27.
Bangladeshi relatives and workers load a body onto a truck on April 27.
An excavator operated by the Bangladeshi Army removes debris on April 26.
Volunteers and rescue workers conduct rescue operations on April 26.
Rescue workers use textile as a slide to move bodies out of the rubble on April 26.
Rescue workers look for trapped garment workers on April 26.
Rescue workers stand on the rubble of the collapsed building on April 26.
Rescue workers search the rubble for victims and survivors on April 26.
A rescue worker looks for trapped workers on April 26.
Bangladeshi army personnel recover a survivor from rubble on April 26, 48 hours after the collapse.
Volunteers and rescue workers assist in rescue operations on April 26.
A physician assists a survivor after he was recovered from the rubble on April 26.
Two bodies clutch each other in the rubble on Thursday, April 25.
People rescue garment workers on April 25.
A Bangladeshi woman shows a picture of her missing daughter-in-law she believes is trapped in the collapsed building on April 25.
Bangladeshi firefighters cut a hole through concrete during rescue operations on April 25 in Savar, a suburb of Dhaka.
Volunteers and rescue workers work at the scene on April 25. 
A woman appears devastated on April 25 after identifying the body of her husband killed in the building collapse.
Bangladeshi garment workers help evacuate a survivor by using a roll of fabric on April 24.
People rescue garment workers on Wednesday, April 24, after the building caved in, leaving a chaotic mass of broken concrete and twisted metal.
Relatives who lost a brother mourn outside a hospital on April 24. 
Rescuers help an injured garment worker to escape from the Rana Plaza building on the outskirts of Dhaka on April 24. 
Civilians help an injured garment worker on April 24. Work was proceeding slowly to avoid causing further collapse, an official said.
Rescue workers search for trapped garment workers in the Rana Plaza building on April 24.
An injured Bangladeshi lies on the hospital floor on April 24.
The injured receive treatment at a hospital on April 24.
An injured person rests in a hospital bed on April 24.
People wait anxiously on April 24 while rescuers search for survivors.
Rescuers help an injured person out of the seventh floor on April 24. 
Civilians help out in rescue efforts at the collapsed building on April 24. 
Hundreds watch the rescue operations on April 24.
People search for garment workers trapped under the debris on April 24.
Rescuers help an injured worker on April 24.
A body is trapped under the damaged building on April 24.
A woman is carried away from the building on April 24.
A rescue worker carries a worker to an ambulance on April 24.
Crowds gather around the collapsed building on April 24.
Rescuers bring out an injured garment worker from the building’s sixth floor.
Seventeen days after a building collapsed in Savar, Bangladesh, rescuers pull Reshma Begum from the rubble on May 10. More than 1,000 people have died since the nine-story garment factory building fell on April 24.
An officer of the Italian cruise line Costa Concordia, Manrico Giampedroni, is found 36 hours after the ship ran aground off the Mediterranean island of Giglio on January 13, 2012. He broke his leg as the liner rolled was was found in a half-flooded dining room, suffering from hypothermia.
A baby, her mother and her grandmother are rescued in eastern Turkey on October 25, 2011, two days after a 7.2-magnitude earthquake killed more than 600 people. Dramatic video showed 2-week-old Arza Karaduman being carried from the debris of a multiple-story building.
More than 9 miles out at sea, a 60-year-old Japanese man is found clinging to the swept-away remnants of his home on March 13, 2011. Hiromitsu Shinkawa was drifting alone for more than two days after a massive Japanese earthquake and tsunami.
Anne Vos, 57, is rescued 24 hours after a five-story building where she worked collapsed during an earthquake in Christchurch, New Zealand, on February 22, 2011. She said she thought she was going to die and had called family and friends to say goodbye. She talked to international media while trapped.
After 69 harrowing days underground and a rescue mission costing up to $20 million, 33 Chilean miners are rescued on October 13, 2010. The mine collapsed on August 5, leaving the workers trapped 2,300 feet beneath the Earth’s surface.
Digging through the mud, Chinese soldiers rescue Liu Ma Shendeng from the second story of an apartment building on August 10, 2010. The 52-year-old man was trapped for 60 hours after massive mudslides buried homes and ripped others apart in China’s Gansu province. The death toll climbed to more than 1,400.
Nine-year-old Ruben van Assouw is the sole survivor of a plane crash in Tripoli, Libya, on May 14, 2010. His parents and brother are among the 103 people killed.
A man identified as Evan Muncie, 28, is found in the ruins of a marketplace, his family tells CNN, nearly a month after a 7.0-magnitude earthquake devastated Haiti on January 12, 2010. He suffered from extreme dehydration and malnutrition, but did not appear to have significant crushing injuries, doctors said.
A 13-year-old girl is found in the Indian Ocean clinging to plane debris after the Yemenia Airways Airbus A310 from France crashed on June 1, 2009. Bahia Bakari was the sole survivor of the crash. She had been flying with her mother.
Naqsha Bibi, 40, is recovered alive from the debris of her collapsed home in Kashmir on December 12, 2005. She reportedly survived on rainwater and rotting food for more than 60 days after an earthquake struck the region on October 8.
Rashida Farooq, a 45-year-old mother of three, is rescued from her home 105 hours after it collapsed in Muzaffarabad, Pakistan, on October 12, 2005. The 7.6-magnitude earthquake that hit the country killed 80,000 people.
A man identified as Jalil, 57, is rescued 13 days after an earthquake in Bam, Iran, on December 26, 2003. He was trapped under a closet and must have had access to water, an Iranian doctor told Reuters.
After being trapped for more than three days, nine miners are rescued from the Quecreek coal mine in Somerset, Pennsylvania, on July 28, 2002. They were caught in a 4-foot-high chamber 240 feet underground after breaching a wall separating their mine from an older, flooded shaft on July 24.
Genelle Guzman-McMillan is rescued from the debris of the World Trade Center 26 hours after the terrorist attack on September 11, 2001. She worked on the 64th floor of the north tower and was walking down a stairwell when the building collapsed. Her body was protected in an air pocket.
Shiran Franco, a 9-year-old Israeli girl, is rescued on August 21,1999, around 100 hours after a building collapsed on her during an earthquake in Cinarcik, Turkey. Her family had been on vacation. Shiran’s twin brother, father and grandparents were found dead, but her mother survived after pulling herself from the building after 30 hours.
Three infants are pulled alive from the crumbled Benito Juarez Hospital seven days after a powerful earthquake hit the Mexican capital on September 19, 1985. With more than 10,000 people killed, the newborns became known as the “miracle babies” of Mexico City.
Sixteen people are rescued 72 days after a Uruguayan Air Force plane crashed in the Andes Mountains on October 13, 1972. They endured frigid temperatures and forced themselves to eat the flesh of dead friends to sustain themselves. A dozen of the 45 passengers on board died in the crash. Others later succumbed to their injuries.
Marching Bangladeshis hold up portraits of relatives missing in the Rana Plaza building collapse on Tuesday, May 14. They’re demanding wages for the missing garment workers and the death sentence for the building owner. Rana Plaza collapsed on April 24 in Savar outside Dhaka; the final death toll stands at 1,127.
Family members of missing workers march on May 14. The Bangladeshi army has wrapped up its search for bodies.
Bangladeshi property tycoon Sohel Rana, center, is escorted to the High Court in Dhaka wearing police-issued body armor as protests calling for his prosecution continue, Tuesday, April 30. 
Bangladeshis march on April 30, demanding capital punishment for Rana in Savar, Bangladesh, outside the capital, Dhaka. 
Garment workers block a street during a protest Monday, April 29.
Bangladeshi garment workers protest in Savar on Saturday, April 27. Four people were arrested and four others are being questioned by police. The building owner has gone into hiding.
Bangladeshi army personnel and police from villagers on Friday, April 26, after protests broke out at the site of a building collapse 48 hours earlier in Savar, outside Dhaka. 
Garment workers block a street in Savar, demanding the arrest of the owner of the Rana Plaza building.
Bangladeshi police fire tear gas at protesters amid the rubble of the building.
Garment workers block a street as they march to demand the arrest of the owner of the Rana Plaza building.
Plainclothes Bangladeshi police brandish sticks as they attempt to break up protests.
Firefighters work after protesters set fire to a spinning mill in Gazipur.
A man cleans up a restaurant after protesters broke its windows.
Syrian army soldiers take control of the village of Western Dumayna north of the rebel-held city of Qusayr on Monday, May 13. Syrian troops captured three villages in Homs province, allowing them to cut supply lines to rebels inside Qusayr town, a military officer told AFP. Tensions in Syria first flared in March 2011 during the onset of the Arab Spring, eventually escalating into a civil war that still rages. This gallery contains the most compelling images taken since the start of the conflict.
Syrian troops move into Dumayna on May 13.
Rebel fighters fire at government forces in the northern Syrian city of Aleppo on Sunday, May 12. 
Smoke rises from an explosion in a Syrian village near the Israeli border on Tuesday, May 7. 
Multiple explosions hit a Syrian village near the Israeli border on May 6.
A photo released by the Syrian Arab News Agency shows destruction from what is said was bomb attack in the Al-Hama area of Damascus on Sunday, May 5. According to the Syrian government, Israel launched an attack on a research center in the Damascus suburbs early Sunday. 
People run for cover after what activists said was shelling by forces loyal to Syria’s President Bashar al-Assad in Syria’s Raqqa province, on May 3.
People walk past a damaged building and multiple destroyed cars at the site of an explosion in Damascus where at least 13 were killed on April 30.
Cleaning takes place following another explosion in an upscale Damascus neightborhood on Monday, April 29. Syrian Prime Minister Wael al-Halqi survived the bombing targeting his motorcade.
A smoke cloud rises from shelling on the the al-Turkman mountains in Syria’s Latakia province on Thursday, April 25.
Searchers use a flashlight as they look for survivors among the rubble created by what activists say was a missile attack from the Syrian regime, in Raqqa province, Syria, on April 25. 
A handout photograph from Syria’s national news agency SANA shows damage and debris from a mortar attack in the suburb of Jarmana near Damascus, Syria, on Wednesday, April 24. The attack killed seven and wounded more than 25, according to activists and state media. No group claimed responsibility for the mortar fire, which SANA said hit a municipality office and a school building.
A Kurdish fighter from the “Popular Protection Units” (YPG) takes position inside a building in the majority-Kurdish Sheikh Maqsood area of Aleppo, on Apri. 21.
People walk past destroyed houses in the northern Syrian town of Azaz on Sunday, April 21. 
Free Syrian Army fighters take positions prior to an offensive against government forces in the Khan al-Assal area, near Aleppo on Saturday, April 20.
Men inspect damage at a house destroyed in an airstrike in Aleppo on April 15.
Syrian and Kurdish rebel fighters walk in the Sheikh Maqsud district of Aleppo on April 14.
A Syrian boy holds an AK-47 assault rifle in the streets of Aleppo on Sunday, April 14.
A female rebel monitors the movement of Syrian government forces in Aleppo’s Sheikh Maqsud neighborhood on April 11.
A rebel runs to avoid sniper fire from Syrian government forces in Aleppo on Thursday, April 11.
Syrian rebels observe the movement of Syrian government forces around Al-Kendi hospital in Aleppo on Wednesday, April 10.
Rescue teams and security forces check out the scene of a deadly car bomb explosion in Damascus on April 8.
The fighting has taken a toll on buildings in Aleppo’s Saladin district, seen here on April 8.
A Syrian rebel runs for cover in Deir ez-Zor on April 2.
A rebel checks for snipers across the street toward the Citadel in Aleppo, Syria, on Saturday, March 30, in this photo taken by iReporter Lee Harper.
A Free Syrian fighter mourns the death of a friend in Aleppo on March 30, in this photo taken by iReporter Lee Harper.
A Syrian opposition fighter runs for cover from Syrian army snipers in Aleppo on Wednesday, March 27.
A Syrian girl covers her face to protect herself from fumes as a street covered with uncollected garbage is fumigated in Aleppo on Sunday, March 24.
A Syrian man and his family drive past damaged buildings in Maarat al-Numan, on Wednesday, March 20.
Syrians carry the body of a Syrian army soldier during a funeral ceremony in Idlib province on Tuesday, March 19.
Syrian rebels take position in Aleppo, the largest city in the country, on March 11.
Syrian men search for their relatives amongst the bodies of civilians executed and dumped in the Quweiq River on March 11.
A Free Syrian Army fighter looks back as smoke rises during fighting between rebel fighters and forces loyal to Syria’s President Bashar al-Assad on the outskirts of Aleppo on Saturday, March 2. 
Residents read Shaam News newspapers published by the Free Syrian Army in Aleppo on March 2.
A member of the Free Syrian Army reacts to the death of a comrade who was killed in fighting, at Bustan al Qasr cemetery in Aleppo on Friday, March 1.
A rebel fighter throws a home-made grenade at Syrian government forces in Aleppo on February 16.
A member of the Free Syrian Army stands with his weapon as he looks at a rainbow in Aleppo on February 16.
A Syrian woman looks through a bus window in Aleppo on February 14.
Free Syrian Army fighters walk through a dust-filled stairwell in Damascus on February 7.
A Syrian rebel gestures at comrades from inside a broken armored personnel carrier in Al-Yaqubia on February 6.
A rebel fighter throws a hand grenade inside a Syrian Army base in Damascus on February 3.
People stand in the dust of a building destroyed in an airstrike in Aleppo, Syria on February 3.
Free Syrian Army fighters run as they enter a Syrian Army base during heavy fighting in the Arabeen neighborhood of Damascus on February 3.
An unexploded mortar shell fired by the Syrian Army sits lodged in the ground in Damascus on January 25.
Fighters from Fateh al Sham unit of the Free Syrian Army fire on Syrian Army soldiers at a check point in Damascus on January 20.
A Free Syrian Army fighter walks between buildings damaged during Syrian Air Force strikes in Damascus on January 19.
A Syrian rebel fighter tries to locate a government jet fighter in Aleppo on January 18. 
Syrian rebels launch a missile near the Abu Baker brigade in Albab on January 16.
A Syrian boy walks near rubbish next to tents at a refugee camp near the northern city of Azaz on the Syria-Turkey border, on January 8.
Syrians look for survivors amid the rubble of a building targeted by a missile in Aleppo on January 7.
A father reacts after hearing of a shelling by forces loyal to Syria’s President Bashar al-Assad in Aleppo on January 3.
A patient smokes a cigarette at Dar Al-Ajaza psychiatric hospital in Aleppo on December 18, 2012. The psychiatric ward, housing around 60 patients, has lacked the means to function properly since fighting broke out there in July.
Syrians mourn a fallen rebel fighter at a rebel base in the al-Fardos area of Aleppo on December 8.
Members of Liwa (Brigade) Salahadin, a Kurdish military unit fighting alongside rebel fighters, monitor the area in the besieged district of Karmel al-Jabl in Aleppo on December 6.
A member of Liwa Salahadin aims at a regime fighter in the besieged district of Karmel al-Jabl in Aleppo on December 6.
Two young boys sit underneath a washline in a refugee camp on the border between Syria and Turkey near Azaz on December 5.
The bodies of three children, who were allegedly killed in a mortar shell attack that landed close to a bakery in Aleppo, on December 2, are laid out for identification by family members at a makeshift hospital at an undisclosed location of the city.
Smoke rises in the Hanano and Bustan al-Basha districts in Aleppo on December 1 as fighting continues through the night.
Damaged houses in Aleppo are seen after an airstrike on November 29.
A Syrian rebel mourns the death of a comrade in Maraat al-Numan on November 20.
Syrians protesters stand on Assad’s portrait during an anti-regime demonstration in Aleppo on November 16.
A Syrian rebel takes cover during fighting against Syrian government forces in Aleppo on November 15.
Syrian opposition fighter Bazel Araj, 19, sleeps next to his pistol in Aleppo on November 11.
A rebel fighter fires at a Syrian government position in Aleppo on November 6.
A Syrian rebel leaps over debris left in the street while running across a “sniper alley” near the Salahudeen district in Aleppo on November 4.
Rebels hold their position in the midst of a battle on November 3 in Aleppo.
A man cries while being treated in a local hospital in a rebel-controlled area of Aleppo on October 31.
A man is treated for wounds after a government jet attacked the Karm al-Aser neighborhood in eastern Aleppo on October 31.
A Syrian rebel interrogates a handcuffed and blindfolded man suspected of being a pro-regime militiaman in Aleppo on October 26.
Smoke rises from a fuel station following a mortar attack as Syrian women walk on a rainy day in the Arqub neighborhood of Aleppo on October 25.
A Syrian rebel fires at an army position in the Karm al-Jabal district of Aleppo on October 22.
A wounded Syrian boy sits on the back of a truck carrying victims and wounded people to a hospital following an attack by regime forces in Aleppo on October 21.
A man lies on the ground after being shot by a sniper for a second time as he waits to be rescued by members of the Al-Baraa Bin Malek Battalion, part of the Free Syria Army’s Al-Fatah brigade, in Aleppo on October 20.
Syrian army soldiers run for cover during clashes with rebel fighters at Karam al-Jabal neighborhood of Aleppo on October 20.
Smoke rises after a Syrian Air Force fighter jet fired missiles at the suburbs of the northern province of Idlib on October 16.
A Syrian opposition fighter stands near a post in Aleppo on October 11.
A Syrian man mourns the death of his father, who was killed during a government attack in Aleppo on October 10.
/A rebel fighter is carried by his friends and laid on a gurney to be treated for gunshot wounds sustained during heavy battles with government forces in Aleppo on October 1.
Syrian rebels help a wounded comrade to an Aleppo hospital after he was injured in a Syrian army strike on September 18.
Free Syria Army fighters are reflected in a mirror they use to see a Syrian Army post only 50 meters away in Aleppo on September 16.
A Syrian man carrying grocery bags tries to dodge sniper fire as he runs through an alley near a checkpoint manned by the Free Syria Army in Aleppo on September 14.
A woman walks past a destroyed building in Aleppo on September 13.
Free Syrian Army fighters battle during street fighting against Syrian army soldiers in Aleppo on September 8.
A Syrian man wounded by shelling sits on a chair outside a closed shop in Aleppo on September 4.
A woman sits in her wheelchair next to her house, damaged by a Syrian air raid, near Homs on August 26.
Members of the Free Syrian Army clash with Syrian army soliders in Aleppo’s Saif al-Dawla district on August 22.
A man mourns in front of a field hospital on August 21 in Aleppo.
Wounded civilians wait in a field hospital after an air strike on August 21 in Aleppo.
People pray during the funeral of a Free Syrian Army fighter, Amar Ali Amero, on August 21.
A man cries near the graves of his two children killed during a recent Syrian airstrike in Azaz on August 20.
A Syrian woman holds her dead baby as she screams upon seeing her husband’s body being covered following an airstrike by regime forces on the town of Azaz on August 15.
A Syrian rebel runs in a street of Selehattin during an attack on the municipal building on July 23.
Syrian rebels hunt for snipers after attacking the municipality building in the city center of Selehattin on July 23.
Members of the Free Syrian Army’s Mugaweer (commandos) Brigade pay their respects in a cemetery on May 12 in Qusayr.
Syrian rebels take position near Qusayr on May 10.
A Free Syrian Army member takes cover in underground caves in Sarmin on April 9.
Rebels prepare to engage government tanks that advanced into Saraquib on April 9.
Men say prayers during a ceremony in Binnish on April 9.
A young boy plays with a toy gun in Binnish on April 9.
A Free Syrian Army rebel mounts his horse in the Al-Shatouria village near the Turkish border in northwestern Syria on March 16, a year after the uprising began.
Syrian refugees walk across a field before crossing into Turkey on March 14.
A rebel takes position in Al-Qsair on January 27.
A protester in Homs throws a tear gas bomb back towards security forces, on December 27, 2011.
A man stands under a giant Syrian flag outside the Umayyad Mosque in Damascus on December 24, 2011.
A member of the Free Syrian Army looks out over a valley in the village of Ain al-Baida on December 15, 2011.
Members of the Free Syrian Army stand in an valley near the village of Ain al-Baida, close to the Turkish border, on December 15, 2011.
Displaced Syrian refugees walk through an orchard adjacent to Syria’s northern border with Turkey on June 14, 2011, near Khirbet al-Jouz.
A Syrian man holds up a portrait of President Bashar al-Assad during a rally to show support for the president in Damascus on April 30, 2011.
Syrians rally to show their support for President Bashar al-Assad in Damascus on April 30, 2011.
A screen grab from YouTube shows thick smoke rising above as Syrian anti-government protesters demonstrate in Moaret Al-Noman on April 29, 2011.
A screen grab from YouTube shows Syrian anti-government protesters run for cover from tear gas fired by security forces in Damascus on April 29, 2011, during the “Day of Rage” demonstrations called by activists to put pressure on al-Assad.
Syrians wave their national flag and hold portraits of al-Assad during a rally to show their support for their leader in Damascus on March 29, 2011.
A woman sits by the hospital bed of a man allegedly injured when an armed group seized rooftops in Latakia on March 27, 2011, and opened fire at passers-by, citizens and security forces personnel according to official sources.
Syrian protesters chant slogans in support of al-Assad during a rally in Damascus on March 25, 2011.
Syrian army soldiers take control of the village of Western Dumayna north of the rebel-held city of Qusayr on Monday, May 13. Syrian troops captured three villages in Homs province, allowing them to cut supply lines to rebels inside Qusayr town, a military officer told AFP. Tensions in Syria first flared in March 2011 during the onset of the Arab Spring, eventually escalating into a civil war that still rages. This gallery contains the most compelling images taken since the start of the conflict.
Syrian troops move into Dumayna on May 13.
Rebel fighters fire at government forces in the northern Syrian city of Aleppo on Sunday, May 12. 
Smoke rises from an explosion in a Syrian village near the Israeli border on Tuesday, May 7. 
Multiple explosions hit a Syrian village near the Israeli border on May 6.
A photo released by the Syrian Arab News Agency shows destruction from what is said was bomb attack in the Al-Hama area of Damascus on Sunday, May 5. According to the Syrian government, Israel launched an attack on a research center in the Damascus suburbs early Sunday. 
People run for cover after what activists said was shelling by forces loyal to Syria’s President Bashar al-Assad in Syria’s Raqqa province, on May 3.
People walk past a damaged building and multiple destroyed cars at the site of an explosion in Damascus where at least 13 were killed on April 30.
Cleaning takes place following another explosion in an upscale Damascus neightborhood on Monday, April 29. Syrian Prime Minister Wael al-Halqi survived the bombing targeting his motorcade.
A smoke cloud rises from shelling on the the al-Turkman mountains in Syria’s Latakia province on Thursday, April 25.
Searchers use a flashlight as they look for survivors among the rubble created by what activists say was a missile attack from the Syrian regime, in Raqqa province, Syria, on April 25. 
A handout photograph from Syria’s national news agency SANA shows damage and debris from a mortar attack in the suburb of Jarmana near Damascus, Syria, on Wednesday, April 24. The attack killed seven and wounded more than 25, according to activists and state media. No group claimed responsibility for the mortar fire, which SANA said hit a municipality office and a school building.
A Kurdish fighter from the “Popular Protection Units” (YPG) takes position inside a building in the majority-Kurdish Sheikh Maqsood area of Aleppo, on Apri. 21.
People walk past destroyed houses in the northern Syrian town of Azaz on Sunday, April 21. 
Free Syrian Army fighters take positions prior to an offensive against government forces in the Khan al-Assal area, near Aleppo on Saturday, April 20.
Men inspect damage at a house destroyed in an airstrike in Aleppo on April 15.
Syrian and Kurdish rebel fighters walk in the Sheikh Maqsud district of Aleppo on April 14.
A Syrian boy holds an AK-47 assault rifle in the streets of Aleppo on Sunday, April 14.
A female rebel monitors the movement of Syrian government forces in Aleppo’s Sheikh Maqsud neighborhood on April 11.
A rebel runs to avoid sniper fire from Syrian government forces in Aleppo on Thursday, April 11.
Syrian rebels observe the movement of Syrian government forces around Al-Kendi hospital in Aleppo on Wednesday, April 10.
Rescue teams and security forces check out the scene of a deadly car bomb explosion in Damascus on April 8.
The fighting has taken a toll on buildings in Aleppo’s Saladin district, seen here on April 8.
A Syrian rebel runs for cover in Deir ez-Zor on April 2.
A rebel checks for snipers across the street toward the Citadel in Aleppo, Syria, on Saturday, March 30, in this photo taken by iReporter Lee Harper.
A Free Syrian fighter mourns the death of a friend in Aleppo on March 30, in this photo taken by iReporter Lee Harper.
A Syrian opposition fighter runs for cover from Syrian army snipers in Aleppo on Wednesday, March 27.
A Syrian girl covers her face to protect herself from fumes as a street covered with uncollected garbage is fumigated in Aleppo on Sunday, March 24.
A Syrian man and his family drive past damaged buildings in Maarat al-Numan, on Wednesday, March 20.
Syrians carry the body of a Syrian army soldier during a funeral ceremony in Idlib province on Tuesday, March 19.
Syrian rebels take position in Aleppo, the largest city in the country, on March 11.
Syrian men search for their relatives amongst the bodies of civilians executed and dumped in the Quweiq River on March 11.
A Free Syrian Army fighter looks back as smoke rises during fighting between rebel fighters and forces loyal to Syria’s President Bashar al-Assad on the outskirts of Aleppo on Saturday, March 2. 
Residents read Shaam News newspapers published by the Free Syrian Army in Aleppo on March 2.
A member of the Free Syrian Army reacts to the death of a comrade who was killed in fighting, at Bustan al Qasr cemetery in Aleppo on Friday, March 1.
A rebel fighter throws a home-made grenade at Syrian government forces in Aleppo on February 16.
A member of the Free Syrian Army stands with his weapon as he looks at a rainbow in Aleppo on February 16.
A Syrian woman looks through a bus window in Aleppo on February 14.
Free Syrian Army fighters walk through a dust-filled stairwell in Damascus on February 7.
A Syrian rebel gestures at comrades from inside a broken armored personnel carrier in Al-Yaqubia on February 6.
A rebel fighter throws a hand grenade inside a Syrian Army base in Damascus on February 3.
People stand in the dust of a building destroyed in an airstrike in Aleppo, Syria on February 3.
Free Syrian Army fighters run as they enter a Syrian Army base during heavy fighting in the Arabeen neighborhood of Damascus on February 3.
An unexploded mortar shell fired by the Syrian Army sits lodged in the ground in Damascus on January 25.
Fighters from Fateh al Sham unit of the Free Syrian Army fire on Syrian Army soldiers at a check point in Damascus on January 20.
A Free Syrian Army fighter walks between buildings damaged during Syrian Air Force strikes in Damascus on January 19.
A Syrian rebel fighter tries to locate a government jet fighter in Aleppo on January 18. 
Syrian rebels launch a missile near the Abu Baker brigade in Albab on January 16.
A Syrian boy walks near rubbish next to tents at a refugee camp near the northern city of Azaz on the Syria-Turkey border, on January 8.
Syrians look for survivors amid the rubble of a building targeted by a missile in Aleppo on January 7.
A father reacts after hearing of a shelling by forces loyal to Syria’s President Bashar al-Assad in Aleppo on January 3.
A patient smokes a cigarette at Dar Al-Ajaza psychiatric hospital in Aleppo on December 18, 2012. The psychiatric ward, housing around 60 patients, has lacked the means to function properly since fighting broke out there in July.
Syrians mourn a fallen rebel fighter at a rebel base in the al-Fardos area of Aleppo on December 8.
Members of Liwa (Brigade) Salahadin, a Kurdish military unit fighting alongside rebel fighters, monitor the area in the besieged district of Karmel al-Jabl in Aleppo on December 6.
A member of Liwa Salahadin aims at a regime fighter in the besieged district of Karmel al-Jabl in Aleppo on December 6.
Two young boys sit underneath a washline in a refugee camp on the border between Syria and Turkey near Azaz on December 5.
The bodies of three children, who were allegedly killed in a mortar shell attack that landed close to a bakery in Aleppo, on December 2, are laid out for identification by family members at a makeshift hospital at an undisclosed location of the city.
Smoke rises in the Hanano and Bustan al-Basha districts in Aleppo on December 1 as fighting continues through the night.
Damaged houses in Aleppo are seen after an airstrike on November 29.
A Syrian rebel mourns the death of a comrade in Maraat al-Numan on November 20.
Syrians protesters stand on Assad’s portrait during an anti-regime demonstration in Aleppo on November 16.
A Syrian rebel takes cover during fighting against Syrian government forces in Aleppo on November 15.
Syrian opposition fighter Bazel Araj, 19, sleeps next to his pistol in Aleppo on November 11.
A rebel fighter fires at a Syrian government position in Aleppo on November 6.
A Syrian rebel leaps over debris left in the street while running across a “sniper alley” near the Salahudeen district in Aleppo on November 4.
Rebels hold their position in the midst of a battle on November 3 in Aleppo.
A man cries while being treated in a local hospital in a rebel-controlled area of Aleppo on October 31.
A man is treated for wounds after a government jet attacked the Karm al-Aser neighborhood in eastern Aleppo on October 31.
A Syrian rebel interrogates a handcuffed and blindfolded man suspected of being a pro-regime militiaman in Aleppo on October 26.
Smoke rises from a fuel station following a mortar attack as Syrian women walk on a rainy day in the Arqub neighborhood of Aleppo on October 25.
A Syrian rebel fires at an army position in the Karm al-Jabal district of Aleppo on October 22.
A wounded Syrian boy sits on the back of a truck carrying victims and wounded people to a hospital following an attack by regime forces in Aleppo on October 21.
A man lies on the ground after being shot by a sniper for a second time as he waits to be rescued by members of the Al-Baraa Bin Malek Battalion, part of the Free Syria Army’s Al-Fatah brigade, in Aleppo on October 20.
Syrian army soldiers run for cover during clashes with rebel fighters at Karam al-Jabal neighborhood of Aleppo on October 20.
Smoke rises after a Syrian Air Force fighter jet fired missiles at the suburbs of the northern province of Idlib on October 16.
A Syrian opposition fighter stands near a post in Aleppo on October 11.
A Syrian man mourns the death of his father, who was killed during a government attack in Aleppo on October 10.
id=”galleryCaption5179″A rebel fighter is carried by his friends and laid on a gurney to be treated for gunshot wounds sustained during heavy battles with government forces in Aleppo on October 1.
Syrian rebels help a wounded comrade to an Aleppo hospital after he was injured in a Syrian army strike on September 18.
Free Syria Army fighters are reflected in a mirror they use to see a Syrian Army post only 50 meters away in Aleppo on September 16.
A Syrian man carrying grocery bags tries to dodge sniper fire as he runs through an alley near a checkpoint manned by the Free Syria Army in Aleppo on September 14.
A woman walks past a destroyed building in Aleppo on September 13.
Free Syrian Army fighters battle during street fighting against Syrian army soldiers in Aleppo on September 8.
A Syrian man wounded by shelling sits on a chair outside a closed shop in Aleppo on September 4.
A woman sits in her wheelchair next to her house, damaged by a Syrian air raid, near Homs on August 26.
Members of the Free Syrian Army clash with Syrian army soliders in Aleppo’s Saif al-Dawla district on August 22.
A man mourns in front of a field hospital on August 21 in Aleppo.
Wounded civilians wait in a field hospital after an air strike on August 21 in Aleppo.
People pray during the funeral of a Free Syrian Army fighter, Amar Ali Amero, on August 21.
A man cries near the graves of his two children killed during a recent Syrian airstrike in Azaz on August 20.
A Syrian woman holds her dead baby as she screams upon seeing her husband’s body being covered following an airstrike by regime forces on the town of Azaz on August 15.
A Syrian rebel runs in a street of Selehattin during an attack on the municipal building on July 23.
Syrian rebels hunt for snipers after attacking the municipality building in the city center of Selehattin on July 23.
Members of the Free Syrian Army’s Mugaweer (commandos) Brigade pay their respects in a cemetery on May 12 in Qusayr.
Syrian rebels take position near Qusayr on May 10.
A Free Syrian Army member takes cover in underground caves in Sarmin on April 9.
Rebels prepare to engage government tanks that advanced into Saraquib on April 9.
Men say prayers during a ceremony in Binnish on April 9.
A young boy plays with a toy gun in Binnish on April 9.
A Free Syrian Army rebel mounts his horse in the Al-Shatouria village near the Turkish border in northwestern Syria on March 16, a year after the uprising began.
Syrian refugees walk across a field before crossing into Turkey on March 14.
A rebel takes position in Al-Qsair on January 27.
A protester in Homs throws a tear gas bomb back towards security forces, on December 27, 2011.
A man stands under a giant Syrian flag outside the Umayyad Mosque in Damascus on December 24, 2011.
A member of the Free Syrian Army looks out over a valley in the village of Ain al-Baida on December 15, 2011.
Members of the Free Syrian Army stand in an valley near the village of Ain al-Baida, close to the Turkish border, on December 15, 2011.
Displaced Syrian refugees walk through an orchard adjacent to Syria’s northern border with Turkey on June 14, 2011, near Khirbet al-Jouz.
A Syrian man holds up a portrait of President Bashar al-Assad during a rally to show support for the president in Damascus on April 30, 2011.
Syrians rally to show their support for President Bashar al-Assad in Damascus on April 30, 2011.
A screen grab from YouTube shows thick smoke rising above as Syrian anti-government protesters demonstrate in Moaret Al-Noman on April 29, 2011.
A screen grab from YouTube shows Syrian anti-government protesters run for cover from tear gas fired by security forces in Damascus on April 29, 2011, during the “Day of Rage” demonstrations called by activists to put pressure on al-Assad.
Syrians wave their national flag and hold portraits of al-Assad during a rally to show their support for their leader in Damascus on March 29, 2011.
A woman sits by the hospital bed of a man allegedly injured when an armed group seized rooftops in Latakia on March 27, 2011, and opened fire at passers-by, citizens and security forces personnel according to official sources.
Syrian protesters chant slogans in support of al-Assad during a rally in Damascus on March 25, 2011.
Rescue workers carry Reshma Begum, 19, to safety on Friday, May 10, a day after her discovery alive amid the wreckage of a building that had entombed her since it collapsed on April 24, in Dhaka, Bangladesh. At least 1,127 people have been confirmed dead from the garment factory building collapse.
Begum, a young female garment worker at the Rana Plaza building before the disaster, addresses the media at the Savar Combined Military Hospital in Savar area of Dhaka on Monday, May 13.
Throngs of reporters crowd around Begum as she speaks publicly for the first time on May 13 about her ordeal in Dhaka. 
Begum is surrounded by media and members of the Bangladeshi military at the hospital where she is recovering in Dhaka on May 13.
A nurse helps Begum through a door as she attends a media conference at the Savar Combined Military Hospital in Dhaka on May 13.
Begum rests in her hospital bed as members of the Bangladeshi military stand beside her at the Savar Combined Military Hospital in Dhaka on Saturday, May 11.
Begum was found in the factory’s basement in a pool of water, according to rescue official Lt. Col. Moazzem Hossain.
Bangladeshi army workers supervise the continued rescue operation using heavy equipment to sift through the rubble on May 10 in Dhaka.
Rescuers workers administer first aid as they carry Begum from the rubble on May 10 in Dhaka.
Begum is pulled alive from the rubble by the rescue workers on May 10, after being buried for 16 days.
Begum recalled that when the collapse of the nine-story building began, she was working on the third floor. She was found in the factory’s basement.
The 19-year-old mother vowed to never again work in the country’s garment industry, where she was earning the equivalent of $60 a month.
Members of the Bangladesh army pray at the site of the collapsed Rana Plaza in Savar near Dhaka on Tuesday, May 14. The army-led effort to search for bodies has ended nearly three weeks after the nine-story building collapsed. The final death toll stands at 1,127.
Relatives of missing garment workers offer prayers in front of the rubble on May 14 in Savar.
A white board at the recovery command center near the disaster is used to track the death toll on Monday, May 13.
Heavy equipment sifts through the rubble of the garment factory building collapse on Sunday, May 12. 
A woman cries holds a portrait of a missing relative believed to be trapped in the rubble of the Rana Plaza building on Saturday, May 11.
Relatives search through a long line of covered decomposing bodies to try to identify their family members on May 11.
An injured worker who survived the building collapse is carried by her husband to collect her wages in Savar near Dhaka, Bangladesh, on Wednesday, May 8.
Garment workers who survived the building collapse line up to collect their salaries in Savar on May 8.
Workers continue rescue and recovery operations on Tuesday, May 7, nearly two weeks after the Rana Plaza building’s collapse outside Dhaka. 
Rescue workers recover a body from the rubble on May 7.
Relatives place a body in the back of a truck on May 7.
A woman attempts to identify one of the bodies kept in a schoolyard on May 7.
Members of the Bangladeshi army and firefighters carry the body of a garment worker from the scene of the building collapse in Savar, outside Dhaka, on Sunday, May 5. 
A woman holds a portrait of her missing relative as she sleeps on Saturday, May 4.
Relatives attempt to identify the bodies of loved ones on May 4.
Rescue workers dig out debris from the Rana Plaza building as Bangladeshi army personnel continue the second phase of a rescue operation using heavy equipment on Friday, May 3.
A woman reacts on May 3 after identifying a body found in the rubble.
A man stands amid the destruction as rescue and army personnel continue recovery operations on May 3.
A woman holds up a picture of a missing person believed to be trapped in the rubble on May 3.
A garment worker rescued from the wreckage of the Rana Plaza building lies in a hospital in Dhaka on Thursday, May 2.
A woman weeps after identifying her daughter’s body in the rubble in Savar on May 2.
Rescue workers move debris as Bangladeshi army personnel continue the second phase of a rescue operation at the site of the collapsed building in Savar on May 2.
A woman mourns before a mass burial in Dhaka on Wednesday, May 1.
Unidentified bodies from the rubble lie on the ground as people gather for a mass burial in Dhaka on May 1.
Workers dig graves during a mass burial of unidentified garment workers on May 1.
Sohel Rana, owner of the collapsed Rana Plaza building, wears police-issued body armor and a helmet while being escorted to court in Dhaka on Tuesday, April 30. Rana was arrested near the Indian border, and protesters called for him to be hanged.
Bangladeshi troops carry the body of a garment worker out of the rubble of the collapsed Rana Plaza building in Savar on April 30.
Clothing with Joe Fresh labels lies in the debris on April 30.
Cranes operated by Bangladeshi army personnel work on Monday, April 29.
Firefighters try to control a blaze that started while they were trying to rescue a woman with heavy equipment on April 29.
Bangladeshi army personnel begin the second phase of the rescue operation using heavy equipment on April 29.
Rescuers look for survivors on Sunday, April 28. The Bangladesh Red Crescent Society says the chances of finding anyone alive in the rubble at this date are remote.
A woman mourns on April 28 at the site of the building collapse in Savar. 
Rescue workers search for survivors on April 28.
Volunteers sleep before they begin more rescue operations on April 28.
Rescue workers carry a victim’s body recovered from the rubble on April 28.
Clothes lie in the rubble on Saturday, April 27.
An arrested owner of a garment factory is escorted to an appearance at the court in Dhaka on April 27. Four people were arrested and four others are being questioned by police.
Relatives hold photos of missing and dead workers outside the factory April 27.
Two Bangladeshi women look at a board with notices posted of missing and dead workers on April 27.
Bangladeshi relatives and workers load a body onto a truck on April 27.
An excavator operated by the Bangladeshi Army removes debris on April 26.
Volunteers and rescue workers conduct rescue operations on April 26.
Rescue workers use textile as a slide to move bodies out of the rubble on April 26.
Rescue workers look for trapped garment workers on April 26.
Rescue workers stand on the rubble of the collapsed building on April 26.
Rescue workers search the rubble for victims and survivors on April 26.
A rescue worker looks for trapped workers on April 26.
Bangladeshi army personnel recover a survivor from rubble on April 26, 48 hours after the collapse.
Volunteers and rescue workers assist in rescue operations on April 26.
A physician assists a survivor after he was recovered from the rubble on April 26.
Two bodies clutch each other in the rubble on Thursday, April 25.
People rescue garment workers on April 25.
A Bangladeshi woman shows a picture of her missing daughter-in-law she believes is trapped in the collapsed building on April 25.
Bangladeshi firefighters cut a hole through concrete during rescue operations on April 25 in Savar, a suburb of Dhaka.
Volunteers and rescue workers work at the scene on April 25. 
A woman appears devastated on April 25 after identifying the body of her husband killed in the building collapse.
Bangladeshi garment workers help evacuate a survivor by using a roll of fabric on April 24.
People rescue garment workers on Wednesday, April 24, after the building caved in, leaving a chaotic mass of broken concrete and twisted metal.
Relatives who lost a brother mourn outside a hospital on April 24. 
Rescuers help an injured garment worker to escape from the Rana Plaza building on the outskirts of Dhaka on April 24. 
Civilians help an injured garment worker on April 24. Work was proceeding slowly to avoid causing further collapse, an official said.
Rescue workers search for trapped garment workers in the Rana Plaza building on April 24.
An injured Bangladeshi lies on the hospital floor on April 24.
The injured receive treatment at a hospital on April 24.
An injured person rests in a hospital bed on April 24.
People wait anxiously on April 24 while rescuers search for survivors.
Rescuers help an injured person out of the seventh floor on April 24. 
Civilians help out in rescue efforts at the collapsed building on April 24. 
Hundreds watch the rescue operations on April 24.
People search for garment workers trapped under the debris on April 24.
Rescuers help an injured worker on April 24.
A body is trapped under the damaged building on April 24.
A woman is carried away from the building on April 24.
A rescue worker carries a worker to an ambulance on April 24.
Crowds gather around the collapsed building on April 24.
Rescuers bring out an injured garment worker from the building’s sixth floor.
Seventeen days after a building collapsed in Savar, Bangladesh, rescuers pull Reshma Begum from the rubble on May 10. More than 1,000 people have died since the nine-story garment factory building fell on April 24.
An officer of the Italian cruise line Costa Concordia, Manrico Giampedroni, is found 36 hours after the ship ran aground off the Mediterranean island of Giglio on January 13, 2012. He broke his leg as the liner rolled was was found in a half-flooded dining room, suffering from hypothermia.
A baby, her mother and her grandmother are rescued in eastern Turkey on October 25, 2011, two days after a 7.2-magnitude earthquake killed more than 600 people. Dramatic video showed 2-week-old Arza Karaduman being carried from the debris of a multiple-story building.
More than 9 miles out at sea, a 60-year-old Japanese man is found clinging to the swept-away remnants of his home on March 13, 2011. Hiromitsu Shinkawa was drifting alone for more than two days after a massive Japanese earthquake and tsunami.
Anne Vos, 57, is rescued 24 hours after a five-story building where she worked collapsed during an earthquake in Christchurch, New Zealand, on February 22, 2011. She said she thought she was going to die and had called family and friends to say goodbye. She talked to international media while trapped.
After 69 harrowing days underground and a rescue mission costing up to $20 million, 33 Chilean miners are rescued on October 13, 2010. The mine collapsed on August 5, leaving the workers trapped 2,300 feet beneath the Earth’s surface.
Digging through the mud, Chinese soldiers rescue Liu Ma Shendeng from the second story of an apartment building on August 10, 2010. The 52-year-old man was trapped for 60 hours after massive mudslides buried homes and ripped others apart in China’s Gansu province. The death toll climbed to more than 1,400.
Nine-year-old Ruben van Assouw is the sole survivor of a plane crash in Tripoli, Libya, on May 14, 2010. His parents and brother are among the 103 people killed.
A man identified as Evan Muncie, 28, is found in the ruins of a marketplace, his family tells CNN, nearly a month after a 7.0-magnitude earthquake devastated Haiti on January 12, 2010. He suffered from extreme dehydration and malnutrition, but did not appear to have significant crushing injuries, doctors said.
A 13-year-old girl is found in the Indian Ocean clinging to plane debris after the Yemenia Airways Airbus A310 from France crashed on June 1, 2009. Bahia Bakari was the sole survivor of the crash. She had been flying with her mother.
Naqsha Bibi, 40, is recovered alive from the debris of her collapsed home in Kashmir on December 12, 2005. She reportedly survived on rainwater and rotting food for more than 60 days after an earthquake struck the region on October 8.
Rashida Farooq, a 45-year-old mother of three, is rescued from her home 105 hours after it collapsed in Muzaffarabad, Pakistan, on October 12, 2005. The 7.6-magnitude earthquake that hit the country killed 80,000 people.
A man identified as Jalil, 57, is rescued 13 days after an earthquake in Bam, Iran, on December 26, 2003. He was trapped under a closet and must have had access to water, an Iranian doctor told Reuters.
After being trapped for more than three days, nine miners are rescued from the Quecreek coal mine in Somerset, Pennsylvania, on July 28, 2002. They were caught in a 4-foot-high chamber 240 feet underground after breaching a wall separating their mine from an older, flooded shaft on July 24.
Genelle Guzman-McMillan is rescued from the debris of the World Trade Center 26 hours after the terrorist attack on September 11, 2001. She worked on the 64th floor of the north tower and was walking down a stairwell when the building collapsed. Her body was protected in an air pocket.
Shiran Franco, a 9-year-old Israeli girl, is rescued on August 21,1999, around 100 hours after a building collapsed on her during an earthquake in Cinarcik, Turkey. Her family had been on vacation. Shiran’s twin brother, father and grandparents were found dead, but her mother survived after pulling herself from the building after 30 hours.
Three infants are pulled alive from the crumbled Benito Juarez Hospital seven days after a powerful earthquake hit the Mexican capital on September 19, 1985. With more than 10,000 people killed, the newborns became known as the “miracle babies” of Mexico City.
Sixteen people are rescued 72 days after a Uruguayan Air Force plane crashed in the Andes Mountains on October 13, 1972. They endured frigid temperatures and forced themselves to eat the flesh of dead friends to sustain themselves. A dozen of the 45 passengers on board died in the crash. Others later succumbed to their injuries.
Marching Bangladeshis hold up portraits of relatives missing in the Rana Plaza building collapse on Tuesday, May 14. They’re demanding wages for the missing garment workers and the death sentence for the building owner. Rana Plaza collapsed on April 24 in Savar outside Dhaka; the final death toll stands at 1,127.
Family members of missing workers march on May 14. The Bangladeshi army has wrapped up its search for bodies.
Bangladeshi property tycoon Sohel Rana, center, is escorted to the High Court in Dhaka wearing police-issued body armor as protests calling for his prosecution continue, Tuesday, April 30. 
Bangladeshis march on April 30, demanding capital punishment for Rana in Savar, Bangladesh, outside the capital, Dhaka. 
Garment workers block a street during a protest Monday, April 29.
Bangladeshi garment workers protest in Savar on Saturday, April 27. Four people were arrested and four others are being questioned by police. The building owner has gone into hiding.
Bangladeshi army personnel and police from villagers on Friday, April 26, after protests broke out at the site of a building collapse 48 hours earlier in Savar, outside Dhaka. 
Garment workers block a street in Savar, demanding the arrest of the owner of the Rana Plaza building.
Bangladeshi police fire tear gas at protesters amid the rubble of the building.
Garment workers block a street as they march to demand the arrest of the owner of the Rana Plaza building.
Plainclothes Bangladeshi police brandish sticks as they attempt to break up protests.
Firefighters work after protesters set fire to a spinning mill in Gazipur.
A man cleans up a restaurant after protesters broke its windows.
Rescue workers carry Reshma Begum, 19, to safety on Friday, May 10, a day after her discovery alive amid the wreckage of a building that had entombed her since it collapsed on April 24, in Dhaka, Bangladesh. At least 1,127 people have been confirmed dead from the garment factory building collapse.
Begum, a young female garment worker at the Rana Plaza building before the disaster, addresses the media at the Savar Combined Military Hospital in Savar area of Dhaka on Monday, May 13.
Throngs of reporters crowd around Begum as she speaks publicly for the first time on May 13 about her ordeal in Dhaka. 
Begum is surrounded by media and members of the Bangladeshi military at the hospital where she is recovering in Dhaka on May 13.
A nurse helps Begum through a door as she attends a media conference at the Savar Combined Military Hospital in Dhaka on May 13.
Begum rests in her hospital bed as members of the Bangladeshi military stand beside her at the Savar Combined Military Hospital in Dhaka on Saturday, May 11.
Begum was found in the factory’s basement in a pool of water, according to rescue official Lt. Col. Moazzem Hossain.
Bangladeshi army workers supervise the continued rescue operation using heavy equipment to sift through the rubble on May 10 in Dhaka.
Rescuers workers administer first aid as they carry Begum from the rubble on May 10 in Dhaka.
Begum is pulled alive from the rubble by the rescue workers on May 10, after being buried for 16 days.
Begum recalled that when the collapse of the nine-story building began, she was working on the third floor. She was found in the factory’s basement.
The 19-year-old mother vowed to never again work in the country’s garment industry, where she was earning the equivalent of $60 a month.
Members of the Bangladesh army pray at the site of the collapsed Rana Plaza in Savar near Dhaka on Tuesday, May 14. The army-led effort to search for bodies has ended nearly three weeks after the nine-story building collapsed. The final death toll stands at 1,127.
Relatives of missing garment workers offer prayers in front of the rubble on May 14 in Savar.
A white board at the recovery command center near the disaster is used to track the death toll on Monday, May 13.
Heavy equipment sifts through the rubble of the garment factory building collapse on Sunday, May 12. 
A woman cries holds a portrait of a missing relative believed to be trapped in the rubble of the Rana Plaza building on Saturday, May 11.
Relatives search through a long line of covered decomposing bodies to try to identify their family members on May 11.
An injured worker who survived the building collapse is carried by her husband to collect her wages in Savar near Dhaka, Bangladesh, on Wednesday, May 8.
Garment workers who survived the building collapse line up to collect their salaries in Savar on May 8.
Workers continue rescue and recovery operations on Tuesday, May 7, nearly two weeks after the Rana Plaza building’s collapse outside Dhaka. 
Rescue workers recover a body from the rubble on May 7.
Relatives place a body in the back of a truck on May 7.
A woman attempts to identify one of the bodies kept in a schoolyard on May 7.
Members of the Bangladeshi army and firefighters carry the body of a garment worker from the scene of the building collapse in Savar, outside Dhaka, on Sunday, May 5. 
A woman holds a portrait of her missing relative as she sleeps on Saturday, May 4.
Relatives attempt to identify the bodies of loved ones on May 4.
Rescue workers dig out debris from the Rana Plaza building as Bangladeshi army personnel continue the second phase of a rescue operation using heavy equipment on Friday, May 3.
A woman reacts on May 3 after identifying a body found in the rubble.
A man stands amid the destruction as rescue and army personnel continue recovery operations on May 3.
A woman holds up a picture of a missing person believed to be trapped in the rubble on May 3.
A garment worker rescued from the wreckage of the Rana Plaza building lies in a hospital in Dhaka on Thursday, May 2.
A woman weeps after identifying her daughter’s body in the rubble in Savar on May 2.
Rescue workers move debris as Bangladeshi army personnel continue the second phase of a rescue operation at the site of the collapsed building in Savar on May 2.
A woman mourns before a mass burial in Dhaka on Wednesday, May 1.
Unidentified bodies from the rubble lie on the ground as people gather for a mass burial in Dhaka on May 1.
Workers dig graves during a mass burial of unidentified garment workers on May 1.
Sohel Rana, owner of the collapsed Rana Plaza building, wears police-issued body armor and a helmet while being escorted to court in Dhaka on Tuesday, April 30. Rana was arrested near the Indian border, and protesters called for him to be hanged.
Bangladeshi troops carry the body of a garment worker out of the rubble of the collapsed Rana Plaza building in Savar on April 30.
Clothing with Joe Fresh labels lies in the debris on April 30.
Cranes operated by Bangladeshi army personnel work on Monday, April 29.
Firefighters try to control a blaze that started while they were trying to rescue a woman with heavy equipment on April 29.
Bangladeshi army personnel begin the second phase of the rescue operation using heavy equipment on April 29.
Rescuers look for survivors on Sunday, April 28. The Bangladesh Red Crescent Society says the chances of finding anyone alive in the rubble at this date are remote.
A woman mourns on April 28 at the site of the building collapse in Savar. 
Rescue workers search for survivors on April 28.
Volunteers sleep before they begin more rescue operations on April 28.
Rescue workers carry a victim’s body recovered from the rubble on April 28.
Clothes lie in the rubble on Saturday, April 27.
An arrested owner of a garment factory is escorted to an appearance at the court in Dhaka on April 27. Four people were arrested and four others are being questioned by police.
Relatives hold photos of missing and dead workers outside the factory April 27.
Two Bangladeshi women look at a board with notices posted of missing and dead workers on April 27.
Bangladeshi relatives and workers load a body onto a truck on April 27.
An excavator operated by the Bangladeshi Army removes debris on April 26.
Volunteers and rescue workers conduct rescue operations on April 26.
Rescue workers use textile as a slide to move bodies out of the rubble on April 26.
Rescue workers look for trapped garment workers on April 26.
Rescue workers stand on the rubble of the collapsed building on April 26.
Rescue workers search the rubble for victims and survivors on April 26.
A rescue worker looks for trapped workers on April 26.
Bangladeshi army personnel recover a survivor from rubble on April 26, 48 hours after the collapse.
Volunteers and rescue workers assist in rescue operations on April 26.
A physician assists a survivor after he was recovered from the rubble on April 26.
Two bodies clutch each other in the rubble on Thursday, April 25.
People rescue garment workers on April 25.
A Bangladeshi woman shows a picture of her missing daughter-in-law she believes is trapped in the collapsed building on April 25.
Bangladeshi firefighters cut a hole through concrete during rescue operations on April 25 in Savar, a suburb of Dhaka.
Volunteers and rescue workers work at the scene on April 25. 
A woman appears devastated on April 25 after identifying the body of her husband killed in the building collapse.
Bangladeshi garment workers help evacuate a survivor by using a roll of fabric on April 24.
People rescue garment workers on Wednesday, April 24, after the building caved in, leaving a chaotic mass of broken concrete and twisted metal.
Relatives who lost a brother mourn outside a hospital on April 24. 
Rescuers help an injured garment worker to escape from the Rana Plaza building on the outskirts of Dhaka on April 24. 
Civilians help an injured garment worker on April 24. Work was proceeding slowly to avoid causing further collapse, an official said.
Rescue workers search for trapped garment workers in the Rana Plaza building on April 24.
An injured Bangladeshi lies on the hospital floor on April 24.
The injured receive treatment at a hospital on April 24.
An injured person rests in a hospital bed on April 24.
People wait anxiously on April 24 while rescuers search for survivors.
Rescuers help an injured person out of the seventh floor on April 24. 
Civilians help out in rescue efforts at the collapsed building on April 24. 
Hundreds watch the rescue operations on April 24.
People search for garment workers trapped under the debris on April 24.
Rescuers help an injured worker on April 24.
A body is trapped under the damaged building on April 24.
A woman is carried away from the building on April 24.
A rescue worker carries a worker to an ambulance on April 24.
Crowds gather around the collapsed building on April 24.
Rescuers bring out an injured garment worker from the building’s sixth floor.
Seventeen days after a building collapsed in Savar, Bangladesh, rescuers pull Reshma Begum from the rubble on May 10. More than 1,000 people have died since the nine-story garment factory building fell on April 24.
An officer of the Italian cruise line Costa Concordia, Manrico Giampedroni, is found 36 hours after the ship ran aground off the Mediterranean island of Giglio on January 13, 2012. He broke his leg as the liner rolled was was found in a half-flooded dining room, suffering from hypothermia.
A baby, her mother and her grandmother are rescued in eastern Turkey on October 25, 2011, two days after a 7.2-magnitude earthquake killed more than 600 people. Dramatic video showed 2-week-old Arza Karaduman being carried from the debris of a multiple-story building.
More than 9 miles out at sea, a 60-year-old Japanese man is found clinging to the swept-away remnants of his home on March 13, 2011. Hiromitsu Shinkawa was drifting alone for more than two days after a massive Japanese earthquake and tsunami.
Anne Vos, 57, is rescued 24 hours after a five-story building where she worked collapsed during an earthquake in Christchurch, New Zealand, on February 22, 2011. She said she thought she was going to die and had called family and friends to say goodbye. She talked to international media while trapped.
After 69 harrowing days underground and a rescue mission costing up to $20 million, 33 Chilean miners are rescued on October 13, 2010. The mine collapsed on August 5, leaving the workers trapped 2,300 feet beneath the Earth’s surface.
Digging through the mud, Chinese soldiers rescue Liu Ma Shendeng from the second story of an apartment building on August 10, 2010. The 52-year-old man was trapped for 60 hours after massive mudslides buried homes and ripped others apart in China’s Gansu province. The death toll climbed to more than 1,400.
Nine-year-old Ruben van Assouw is the sole survivor of a plane crash in Tripoli, Libya, on May 14, 2010. His parents and brother are among the 103 people killed.
A man identified as Evan Muncie, 28, is found in the ruins of a marketplace, his family tells CNN, nearly a month after a 7.0-magnitude earthquake devastated Haiti on January 12, 2010. He suffered from extreme dehydration and malnutrition, but did not appear to have significant crushing injuries, doctors said.
A 13-year-old girl is found in the Indian Ocean clinging to plane debris after the Yemenia Airways Airbus A310 from France crashed on June 1, 2009. Bahia Bakari was the sole survivor of the crash. She had been flying with her mother.
Naqsha Bibi, 40, is recovered alive from the debris of her collapsed home in Kashmir on December 12, 2005. She reportedly survived on rainwater and rotting food for more than 60 days after an earthquake struck the region on October 8.
Rashida Farooq, a 45-year-old mother of three, is rescued from her home 105 hours after it collapsed in Muzaffarabad, Pakistan, on October 12, 2005. The 7.6-magnitude earthquake that hit the country killed 80,000 people.
A man identified as Jalil, 57, is rescued 13 days after an earthquake in Bam, Iran, on December 26, 2003. He was trapped under a closet and must have had access to water, an Iranian doctor told Reuters.
After being trapped for more than three days, nine miners are rescued from the Quecreek coal mine in Somerset, Pennsylvania, on July 28, 2002. They were caught in a 4-foot-high chamber 240 feet underground after breaching a wall separating their mine from an older, flooded shaft on July 24.
Genelle Guzman-McMillan is rescued from the debris of the World Trade Center 26 hours after the terrorist attack on September 11, 2001. She worked on the 64th floor of the north tower and was walking down a stairwell when the building collapsed. Her body was protected in an air pocket.
Shiran Franco, a 9-year-old Israeli girl, is rescued on August 21,1999, around 100 hours after a building collapsed on her during an earthquake in Cinarcik, Turkey. Her family had been on vacation. Shiran’s twin brother, father and grandparents were found dead, but her mother survived after pulling herself from the building after 30 hours.
Three infants are pulled alive from the crumbled Benito Juarez Hospital seven days after a powerful earthquake hit the Mexican capital on September 19, 1985. With more than 10,000 people killed, the newborns became known as the “miracle babies” of Mexico City.
Sixteen people are rescued 72 days after a Uruguayan Air Force plane crashed in the Andes Mountains on October 13, 1972. They endured frigid temperatures and forced themselves to eat the flesh of dead friends to sustain themselves. A dozen of the 45 passengers on board died in the crash. Others later succumbed to their injuries.
Marching Bangladeshis hold up portraits of relatives missing in the Rana Plaza building collapse on Tuesday, May 14. They’re demanding wages for the missing garment workers and the death sentence for the building owner. Rana Plaza collapsed on April 24 in Savar outside Dhaka; the final death toll stands at 1,127.
Family members of missing workers march on May 14. The Bangladeshi army has wrapped up its search for bodies.
Bangladeshi property tycoon Sohel Rana, center, is escorted to the High Court in Dhaka wearing police-issued body armor as protests calling for his prosecution continue, Tuesday, April 30. 
Bangladeshis march on April 30, demanding capital punishment for Rana in Savar, Bangladesh, outside the capital, Dhaka. 
Garment workers block a street during a protest Monday, April 29.
Bangladeshi garment workers protest in Savar on Saturday, April 27. Four people were arrested and four others are being questioned by police. The building owner has gone into hiding.
Bangladeshi army personnel and police from villagers on Friday, April 26, after protests broke out at the site of a building collapse 48 hours earlier in Savar, outside Dhaka. 
Garment workers block a street in Savar, demanding the arrest of the owner of the Rana Plaza building.
Bangladeshi police fire tear gas at protesters amid the rubble of the building.
Garment workers block a street as they march to demand the arrest of the owner of the Rana Plaza building.
Plainclothes Bangladeshi police brandish sticks as they attempt to break up protests.
Firefighters work after protesters set fire to a spinning mill in Gazipur.
A man cleans up a restaurant after protesters broke its windows.
